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KMID : 0043320050280111224
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Archives of Pharmacal Research
2005 Volume.28 No. 11 p.1224 ~ p.1227
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Cytotoxic Constituents from the Whole Plant of Corydalis pallida
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Kim Hyang-Rim
Min Hye-Young
Jeong Yeon-Hee
Lee Sang-Kook
Lee Nam-Sook
Seo Eun-Kyoung
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Abstract
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Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with values of 3.2 and 3.4 g/mL, respectively. Ntrans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.
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KEYWORD
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Corydalis pallida, Papaveraceae, Berberine, N-trans-Feruloylmethoxytyramine, N-trans-Feruloyltyramine, Cytotoxicity
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